CHARACTERIZATION OF GREEN SYNTHESIZED SILVER NANOPARTICLES USING MORINGA OLEIFERA LEAF EXTRACT FOR ANTIHYPERTENSIVE ACTIVITY

Abstract

According to WHO more than 80% of the world’s population relies on traditional medicine for their primary health need. Hypertension is a common problem facing many peoples today. Although billions of dollars are spent annually for the treatment and detection of cardiovascular disease, there is great interest, in the use of herbs for the treatment of hypertension and cardiovascular disease. Herbs and plants contain many phytochemicals that have been effective in the treatment of hypertension. In the present study, initially leaves of moringa oleifera was extracted with ethanol using Soxhlet apparatus then it has been formulated as a silver nanoparticle using silver nitrate by green synthesis method. The synthesized nanoparticle was evaluated using UV-Visible spectroscopy, Transmission Electron Microscopy and Zeta sizer. The results show the incorporation of the silver ions in the extract and also the reduction of particle size in nano range. The invitro antihypertensive activity was carried out using Angiotensin converting enzyme inhibitor assay for the standard drug and the formulated silver nanoparticle and found that the percentage inhibition of silver nanoparticle complies with the percentage inhibition of standard drug. It is seen that the silver nanoparticles have good hypertensive inhibition. Hence silver nanoparticles of moringa oleifera leaf extract can be used as a potential alternative to traditional synthetic drugs by using this non-toxic safe way of green synthesis.